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How do we discover future therapies?

Ecrins Therapeutics put in place an original and disruptive drug discovery engine allowing to discover and develop patentable molecules directed against new therapeutic targets. The founders of the company, experts in cell biology, live cell microscopy, and biochemistry, have developed a unique concept based on the creation of cellular models of human cancer. In other words, instead of the endless search of molecules killing established cancer cell lines, we create cells with a well-defined cancer-related phenotype (physical trait). We then use these cell models of human cancer to find small molecules or biologicals (therapeutic antibodies) which can reverse the target cancer hallmark.
The discovery of bioactive molecules is followed by the identification of their targets and characterization of the mechanism of action (MOA). The proof-of-concept of this drug discovery engine has already been achieved through the development of the ET-D5 program. The scale-up of this approach is ongoing with two early-stage projects.